Obesity and depression: brain work and metabolic problems

Posted on July 22, 2019  in Uncategorized

Most of the people know little about inflammation. They believe that it is formed after injury or during infection, when swelling, redness and pain develop in the affected area. However, this process also occurs inside the body, including with metabolic disorders and weight gain, causing changes in the brain. In addition to all other problems, the system   inflammation   may play a role in the development of obesity and depression. But how are they related?

Inflammation: a role in the body

If people hear about inflammation, they most often represent infected wounds or colds. And usually this term is associated with painful sensations, rather than internal healing processes. Any damage to the tissues (skin, mucous membranes, internal organs) immediately causes inflammation in order to restore the integrity of the body and normalize the metabolism.

But inflammation can also occur when it is not needed at all, and this can cause problems. In some people, the inflammation is sluggish and barely noticeable, gradually leading to serious metabolic disorders. Currently, many experts believe that this type of chronic inflammation is responsible for a number of chronic diseases, including depression and obesity, heart and vascular lesions.

When inflammation spreads to the beta cells of the pancreas, diabetes develops. When it affects the immune system, arthritis, psoriasis and many other diseases occur. This type of inflammation (systemic) gradually spreads, damaging organs and causing metabolic disorders.

Weakened brain signals

When inflammation becomes systemic, it not only damages the organs, but also prevents the brain from sending signals to the rest of the body. In many pathological conditions, problems begin with the hypothalamus. This is the command center of the brain, and it receives various hormonal signals that tell the brain when a person is tired or hungry, what to do with incoming calories. Then the brain makes a decision, sending guiding impulses.

When systemic inflammation occurs, proteins called inflammatory cytokines distort these hormonal signals. As a result, inflammation can cause conditions such as depression and   obesity, which were linked together long before the effects of the inflammatory response were clarified.

When depressed, these cytokines negatively affect the brain, causing a variety of depressive symptoms, such as sad mood, fatigue, sleep disorders, and social and behavioral disorders. Similarly, inflammation leads to obesity, although in this case the effect on the brain is more complex and includes additional conditions.

Metabolic syndrome, overweight

Systemic inflammation has recently been associated with metabolic syndrome, which is a group of symptoms that increase the risk of chronic diseases such as heart disease, stroke and diabetes. These symptoms include hypertension, low HDL cholesterol (“good” cholesterol), elevated glucose and triglycerides in the blood, as well as excess weight, especially in the waist area. Most people with metabolic syndrome are obese and inactive, so these symptoms have become associated with being overweight. However, many people who even have severe obesity do not have signs of metabolic syndrome. Then they fall into the category of people with metabolically healthy obesity.

This means that although there is excess weight, but if you perform blood tests and evaluate the metabolism, there are no serious metabolic abnormalities, since these people probably do not have systemic chronic inflammation. Experts cannot argue that obesity causes inflammation, but changes in metabolism typical of systemic inflammation often lead to an accumulation of excess weight.

Depression and metabolic disorders

The links between inflammation and depression are complex, and scientists are only now beginning to understand how these diseases affect each other. Although severe clinical   depression   can lead to metabolic changes that cause inflammation, experimental studies have shown that a systemic inflammatory response, in turn, can also contribute to the development of depression. A 2015 study found that people with depression have a 30% higher inflammation in the brain. It was one of the first studies that specifically showed that a systemic inflammatory response and impaired metabolism in depression are detected, even when other conditions are absent.

However, depression is a complex pathology and can hardly be caused by inflammation alone, similar to obesity.

Many people usually think of depression as a mental disorder or mental health problem. But depression is a disorder with deep biological roots. This is the same physical problem as the mental one, it significantly affects the metabolism, the metabolism of hormones and the work of the organs.

Fight against obesity and systemic inflammation

Identifying a systemic inflammatory response is an expensive procedure. It is carried out only in scientific laboratories. But the patients themselves can help their body cope with the systemic inflammatory response, as well as control weight gain, while fighting obesity.

Of course, the best medicine in this case is diet. Some traditional products of our table help to increase the level of inflammatory cytokines. The two biggest culprits are omega-6 fatty acids and excess insulin, caused by the consumption of starchy carbohydrates.

To reduce the negative effects, you need foods with omega-3 polyunsaturated fatty acids and high polyphenol content found in fruits and vegetables. These good fats and bright fruits, vegetables, along with lean protein, make up most of the anti-inflammatory diet. Along with diet, a healthy lifestyle and stress management help reduce inflammation, especially in the brain. This is especially important when there are obesity and metabolic syndrome.

How does Pregabalin compared to Gabapentin in the treatment of neuropathic pain.

Treatment of neuropathic pain , Pregabalin in comparison with Gabapentin

Neuropathic pain is a current problem of modern life, difficult responding to treatment. The purpose of the present overview comes down to assessment of efficiency of Pregabalin and Gabapentin at treatment of peripheral and central neuropathic pain. In clinical trials of high level. Materials and methods. The present overview included randomized controlled studies.

Pregabalin is a medicine with anti-epileptic effect which allows to reduce severity of spasms of cross-striped skeletal muscles. Pregabalin is an analog of the main brake mediator of structures of central nervous system. Pregabalin is an analog of piperidic acid ((S)-3 (aminomethyl)-5-methylhexane acid). 

While Gabapentin on the chemical structure practically does not differ from piperidic acid. It is acid which is a brake neurotransmitter of central nervous system. The symptomatic anticonvulsant interferes with development of epileptic attacks. Also stops neuropathic pains. These pains arise because of pathological excitement of the central nervous system or neurons.

Gabapentin does not influence radioligand linking of GAMK with receptors. This drug is not metabolized in not proteinogenic acid. Also does not inhibit capture of a brake neurotransmitter. In concentration up to 100-110 microns the operating components do not show affinity to:

  • glutamate;
  • kainantny;
  • benzodiazepine;
  • glycine;
  • cholinergic;
  • and to other specific receptors.

Pregabalin is effective at patients with diabetic neuropathy and post-herpetic neuralgia. Clinical trials showed. Reduction of the index of pain by 50%, approximately at 35% of patients against the background of use of Pregabalin and for 18% of the patients receiving placebo was noted. The patients receiving Pregabalin and not noting drowsiness. Reduction of the index of pain by 50% was noted in 33% of cases. The patients accepting placebo at them this indicator was 18%. Drowsiness was noted at 48% of patients who received Pregabalin medicine. And at 16% of patients the receiving placebos. In addition at patients with neuropathic pain of Pregabalin reduced a sleep disorder. Improved the general condition and quality of life. The severity of allodynia at post-herpetic neuralgia decreased. Uneasiness at the central neuropathic pain. The need for morphine at neuropathic pain owing to cancer decreased. The severity of the constipations caused by it decreased. Effects of non-steroidal anti-inflammatory drugs (amplified at chronic lower back pain).

About gabapentinoids

Mechanism of action Gabapentin. It is ability of medicinal metabolites, to activate additional ion channels. In used of Neurontin the new formed peptide receptors were found. In a limbic system and a neocortex. These receptors carry out successful antiepileptic activity of active ingredients. At use of Gabapentin side effects arise considerably less than at reception of other anticonvulsants. If undesirable reactions are shown, then they are shown at patients at the very beginning of pharmacotherapy. It considerably facilitates life both to patients, and their treating to doctors.

Research of mechanical properties in molecular crystals in the field of a crystal engineering. Qualitative mechanical properties are necessary for production of pharmaceutical important substances in drugs, suitable for use. Monocrystals help to correlate microscopic structure to macroscopic properties for potential design. Hydrate forms of two anticonvulsant zwitterionic drugs, Pregabalin and Gabapentin are examples of crystal materials which show macroscopic plasticity. Direct comparison of these structures with their waterless analogs which are brittle allows to assume that presence of water is crucial for plasticity. On the contrary, structural features, such as molecular packing and anisotropic distribution of strong and weak interactions, seem less important.

In recent years abuse cases gabapentinoid became frequent (gabapentin or pregabalin). Data on pharmacovigilance from Reporting system on side effects of the Food and Drug Administration (FAERS) provide useful information about messages about side effects (ADE) for detection of a signal save gabapentin damit.

Though it is traditional was not considered as abuse drugs, for the analyzed terms more than 600 cases of abuse were registered that causes the necessity of further studying and standard investigation.

Each drug has pluses and minuses, in too time these drugs are similar in properties and origin.

Problems of COPD: depression, respiratory disorders

Posted on July 18, 2019  in Uncategorized

The presence of patients with manifestations of COPD does not add optimism. According to doctors, the symptoms of this disease are incurable, with time, respiratory disorders will progress, especially if you do not heal and do not radically change your whole lifestyle. Constant exercises to improve pulmonary ventilation can be tiring, changes in life and medication, unpleasant symptoms and attacks of breathlessness can provoke depression. What advice can a doctor give in this situation, to which questions of patients does he most often give answers?

Breathing problems: alarms

The human brain is designed to protect its own body and keep it alive. Deep in the human brain is a department that constantly tests its own   blood to make sure that the body receives enough oxygen, and the lungs breathe clean, healthy air. If he detects problems with breathing and gas concentration, he sends an alarm. It is perceived by the human body as a sudden attack of anxiety, unexplained anxiety, or panic. This feeling encourages a person to get up and leave the place where his breathing is disturbed.

With COPD, the patient often has breathing problems, and anxiety with asthma attacks can become common symptoms. As a result, a person may feel irritation or anxiety for a long time, or experience a panic attack when he is in a hurry, has run, or has felt a strong or strong smell. There may be more frequent   breathing, shortness of breath, asphyxiation and indisposition.

It is important to understand that this condition is common in people with COPD, it is not associated with emotional or mental disorders – it is the body’s response to hypoxia. With the help of a doctor, you can do a number of things that help reduce anxiety and choking.

Dealing with anxiety in sickness

Panic and anxiety, anxiety are common problems for people with obstructive pulmonary disease. This may be caused by attempts by the brain to eliminate hypoxia or the result of all changes caused by a painful condition. Below is a list of some of the problems that a patient may encounter with the disease:

  • The patient notes sleep problems because he is constantly worried.
  • He can sit quietly and suddenly begin to choke.
  • A person almost always worries about when he has a new episode of difficulty breathing.
  • It seems to him that if he leaves the house, he will become worse.
  • He is afraid of falling into elevators, on airplanes or on bridges, trying not to go to crowded places.
  • The patient avoids communication, constantly feels uncomfortable, is in anticipation of trouble.

This is also true for people who feel depressed due to their illness. They dream of “rest” from COPD. Sometimes this leads to alcohol abuse, complete isolation from people, which threatens to kill the patient more quickly.

Doctor’s advice for anxiety

It is unrealistic to hope that the patient will be able to completely get rid of anxiety. But the doctor may advise working in the direction of the “ideal level of anxiety.” In this ideal state, the patient accepts that he has a chronic and severe illness, but at the same time, the doctor will recommend certain techniques that can be used to alleviate the symptoms and improve the general condition.

In the long run, a person is likely to go through periods when he experiences too much, but at other times it is worthwhile to take more care of his condition. These vibrations are completely normal. The goal should be to find the “right” number of experiences that will help the patient save his life and control the manifestations of the disease.

Depression in COPD: the danger?

COPD can make a person feel tired all the time or makes it difficult to sleep. This can lead to fatigue, loss of appetite, and some medicines can change the taste of food or form side effects. The patient may be tied to an oxygen cylinder or suffer from a chronic cough, he is increasingly reluctant to communicate with others. Perhaps the patient was active all his life and now can not do what he once liked. All of these problems can put a person with COPD at risk of developing depression.

Of course, the development of COPD introduces significant limitations in the usual life, and much in life will have to be abandoned. Because of this is quite possible   depression, especially when feeling unwell. It is understandable that the patient may experience anger, sadness, and a sense of loss. These are quite natural reactions in the majority of chronically ill patients. But if the feelings are all-pervasive and do not allow a person to fully take care of himself, he needs to talk to his doctor: most likely the depression is already quite difficult. This condition is very common and is treatable through psychotherapy or drug treatment.

Signs of Depression in Patients with COPD

For patients with COPD, a number of symptoms are highlighted, indicating a possible depression. If the patient responds positively to five or more points, you should consult a doctor about depression. So, it is possible:

  • The feeling of sadness is more than 4-5 days a week for several weeks in a row;
  • Restless sleep, insomnia, or sleep that is disturbed by early wakefulness or difficulty falling asleep;
  • Excessive sleep, with difficult waking in the morning;
  • Decreased interest in your loved ones or activities;
  • Reducing energy, activity and motivation for any action;
  • Difficulties with concentration of attention and solving everyday problems;
  • Altered appetite, sharply increased or pathologically reduced;
  • Low self-esteem;
  • Feeling hopeless that a person will never feel better, no matter what happens;
  • Attacks of crying, occurring more often than usual;
  • A feeling of irritation regarding all aspects of life;
  • Excessive guilt;
  • Suicidal thoughts or a desire for life to end;
  • Inability to laugh or enjoy life.

At one time or another, most people with COPD think about various issues that are difficult to discuss with anyone, including doctors and family members. This concerns the terminal stages of the disease and the need to stay in a hospital or hospice, as well as the issue of life expectancy.

When winter is not happy: seasonal depression in children

Posted on July 14, 2019  in Uncategorized

December 22 is a turning point when the longest night is recorded and after twilight time begins to decline. Soon the New Year holidays, children’s holidays – so why are some of us not happy?

Many people think that depression in the dark season is a lot of adults. However, children are equally susceptible to it, because they also lack sunshine, just like their parents. How does this condition manifest itself in childhood and how to help your child survive this difficult period?

Causes of Seasonal Depression

The child, just like an adult, needs ultraviolet rays. They are no less important than water and fresh air. Residents of the northern regions of our country see the sun several hours a day from mid-November to mid-January, while those living in the Arctic have no ultraviolet rays for a whole month. This can not but affect the full-fledged work of the human body: both an adult and a child.

When exposed to UV light on the skin of the child, the brain produces a hormone   serotonin. It evokes a feeling of joy, happiness, self-confidence, a positive attitude and the need for physical activity. The production of serotonin and the enzymes that metabolize it is controlled by the genetic apparatus. That is, there are children who do not react at all to the duration of the daylight hours. But there are those who, with an ultraviolet deficit, experience the full range of negative states united by the same term “seasonal depression.” It is about the latter and will be discussed in our article.

Seasonal depression in children of different ages

Seasonal depression manifests itself in all   children   about the same, but small age differences still can be identified.

  • Children of the first 2 years of life are naughty, infants prefer to stay long at her mother’s breast, which gives them the desired comfort. Changes in food preferences are observed, children can refuse both their usual food and resist the new one. Often in the dark season there is a slowdown in weight gain and height, which can frighten parents.
  • Preschool children (from 2 to 6 years). Short daylight hours and the kids who attend kindergarten. They become slow, often in a depressed mood, unwilling to play on their own and constantly require parental attention.
  • Junior schoolchildren may have trouble concentrating when performing lessons. They are often distracted, long behind a page in a textbook or one example. Often complain of fatigue, it is difficult to wake them to school in the morning. They often develop colds, but the cause is not only the viruses themselves, but their unwillingness to go anywhere. To lie in bed and watch cartoons is what the elementary school children really need in the dark season.
  • Adolescence is extremely difficult, and in the early winter period, children can throw a number of problems to their parents. They become capricious, reticent, depressive, melancholic, often suffer from unrequited love. They lose interest in sports, clubs, meetings with friends.

How to help your child cope with seasonal depression

Parents are also people, and in the dark season they also suffer from a lack of sunlight. Problems with children add to their troubles and further increase the depressive mood. However, their task is to help their child survive this difficult period. Immediately after the celebration of New Year and Christmas, the light day begins to gradually increase, and the mood will gradually improve.

But the whole of December the child needs increased attention, participation in his problems and he needs to be given all possible assistance. To do this, follow these rules.

  • Physical contact All the time that parents spend at home with   as a child, they should spend it together. Read books, draw, engage in creative work or just talk, lying under a warm blanket with a cup of warm cocoa. Hugs do not happen much, they will benefit both.
  • Attention to problems. It often happens that parents do not take the problems of the baby seriously. However, he also suffers from the fact that his favorite airplane was broken, as well as adults from problems at work. It is worth trying as carefully to treat its complexities, as we would like to be treated to their own. It is necessary to carefully listen to the child (or at least pretend), because for him the support of parents is very important.
  • No diets. In the dark and cold season, the body lacks endorphins – pleasure hormones. Parents should make sweet gifts to their children more often, let it be just a little candy per day – it will definitely improve the mood. Cocoa, tea with waffles, a couple of chocolate slices – the best remedy for depression and depression.
  • More lighting. There is nothing more pleasant than to enter a warm, cozy home after a long journey home in bad weather. However, it is very important that in the dark season the lighting in the nursery was very bright. To do this, you can additionally purchase a lamp, lamp, floor lamp. The mood is added by lanterns hanging on the walls, festoons and Christmas-tree tinsel. Children should feel cozy and warm, but in order for them to want to play, read or go about their business, it is worthwhile to take care of the lighting in advance.
  • Socializing with friends. Children are always more fun to play with others than to spend time alone, even with a million toys. On weekends, you should try to get out “in people” more often, invite classmates to visit, attend interesting exhibitions, children’s programs.

What symptoms should alert parents

In most cases, seasonal depression in a child passes without a trace in the first days after the celebration of the new year. But, nevertheless, in some cases, it can be delayed. The following symptoms should alert   parents. When they appear, you should seek help from a specialist:

  • the child has become so apathetic, he refuses to play and do something at all,
  • baby completely refuses to eat
  • the child constantly insists that he is the worst of all, nobody needs him, he does not succeed,
  • school performance has become extremely bad, and the teacher pays attention to it,
  • the child expresses suicidal thoughts, or the parents were able to find confirmation of this somewhere (for example, in a personal diary, notebooks, social networks),
  • the child began to show aggression towards parents, sisters, brothers, pets,
  • the kid constantly says that he is tired, the classes that he previously likes have ceased to interest him completely.

It is necessary to show the child to a child psychologist or psychiatrist. After talking with him, he will tell you how to help him. In rare cases, antidepressants are prescribed.

Seasonal depression in winter is a temporary phenomenon, and the love of parents is the main remedy for overcoming this condition.

What substance is bimatoprost?

Posted on July 12, 2019  in Uncategorized

Bimatoprost is a synthetic analogue of natural prostaglandins.

In medicine, this class of chemicals is used to reduce intraocular pressure; Bimatoprost is part of a number of anti-glaucoma drugs.


  1. Open-angle glaucoma.
  2. Various cases of ocular hypertension.
  3. It can be used for eyelash hypotrichosis.

Instructions for use

Eye drops with bimatoprost apply   once a day, one drop in the conjunctival sac of the sore eye.

It is necessary to use this drug strictly.   as prescribed by a doctor, exactly following his prescriptions.

Side effects

  1. Itching and burning of the mucous membrane of the eyeball.
  2. Redness of the eyelids.
  3. Congestion hyperemia.
  4. The appearance of hyperpigmentation of the eyelid skin.
  5. Strengthening the growth of eyelashes.
  6. Change the original shade of the eyelashes.
  7. Possible change of direction and density of eyelash growth.
  8. The development of dry eye syndrome.
  9. Lowering intraocular pressure.


  1. Pregnancy.
  2. Age up to 18 years.
  3. Breastfeeding period.
  4. Allergic reactions and all cases of hypersensitivity to the components of the drug.

Particular caution in the use of drugs on the basis of bimatoprost must be observed in the following cases:

  • aphakia and pseudo-apacia;
  • damage to the posterior lens capsule of any nature;
  • the existence of a risk of macular edema;
  • previous long-term therapy of diabetes;
  • elevated blood cholesterol;
  • nephropathy of varying severity;
  • hypotension of various origin and varying severity;
  • uveitis: against the background of the use of bimatoprost, the disease may progress.


Analogues of this drug can be considered all drugs, the active ingredient of which is bimatoprost. Including   Kareprost, actively positioned on the market, as a means of enhancing the growth of eyelashes.

Important points:

  1. The effect of the drug Kareprost is not constant. It is necessary to maintain regular repeated courses.
  2. As a result of using Kareprost, the nature and uniformity of growth of eyelashes, the direction of their growth, thickness, even color can change.
  3. During the course of Kareprost, it is strongly recommended to control the intraocular pressure (in order to avoid permanent violations of it).
  4. The color of the iris may behave quite unpredictably: during the application of Kareprost, there is a high likelihood of its hyperpigmentation (especially, with its initial dark shade); the duration of this effect is unknown, but in most cases this effect is reversible.
  5. When using Kareprost, you should also keep in mind the possibility of hyperpigmentation of the eyelid skin. This phenomenon is also considered reversible.
  6. In the case of wearing contact lenses, they should be removed fifteen minutes before using Kareprost and re-installed no earlier than at the same time after use.
  7. Do not apply Kareprost drops to patients under the age of 18 years.
  8. In case of undesirable side effects, it is necessary to immediately discontinue the use of the agent and seek advice from an ophthalmologist.
  9. Since Kareprost is an ophthalmologic pharmaceutical product, when deciding on the use of Kareprost to enhance eyelash growth, it is more appropriate to be guided by the opinion of an ophthalmologist and not by reviews on advertising sites.

Situations requiring consultation of an ophthalmologist:

  • the appearance of any of the undesirable side effects indicated in the instructions for the medicinal product;
  • decrease in visual acuity on the background of the use of funds;
  • trauma of the organ of vision;
  • infection of the organ of sight;
  • the occurrence of any unusual symptoms or events that developed during the treatment with Kareprost.

Bimatoprost is a drug that is a component of ophthalmic drugs used in the fight against certain types of glaucoma.

However, today the drug has become widespread as a cosmetic tool that promotes the strengthening and growth of eyelashes.

The drug is indicated for:

  • open-angle glaucoma;
  • increased intraocular pressure;
  • hypotrichosis of eyelashes, their loss;
  • weak growth of eyelashes.

Drops with Bimatoprost

The substance is used in some medicines.   The most common are Bimatoprost, Latisse and Gunfort drops.


Bimatoprost stimulates blood circulation, activates enhanced metabolism and provides blood flow to the eyelashes. Due to this, nutrients better penetrate the hair follicle, which ensure the growth and health of eyelashes. Also, the drug increases their volume and length. In addition, it can be applied to the eyebrows.

Drops are applied to the upper eyelid on the roots of the eyelashes with a special applicator 1 time per day. Course duration is   3 months. In case of contact with other areas of the eye, it is immediately removed with a cotton pad.


Latisse is designed to strengthen eyelashes, nourish hair follicles and general recovery. Thanks to this tool the eyelashes begin to grow faster, while becoming thicker and darker.

It is necessary to use means once a day before going to bed. Before use, you must thoroughly clean the face of dirt and cosmetics and remove contact lenses. In the package there are disposable sterile applicators, with the help of which the drops are applied to the upper eyelid along the lash line. The tool should not leak out and, if necessary, remove excess moisture.

For each eye, a new applicator is used, and after use they must be discarded.


The composition of drops Hanforth includes not only bimatoprost, but also timolol.   Together they reduce intraocular pressure, increase the outflow of intraocular fluid, and reduce its formation. Gunfort is directly used as   means to fight glaucoma.   G enfort is applied 1 time a day in the morning. It is necessary to drip 1 drop into the conjunctival sac of the affected eye.

special instructions

After the use of the drug may be temporarily lost clarity, so you need to wait some time before you get behind the wheel or do work that requires special attention.   The product must not be applied if contact lenses are worn. After using the drug, you need to wait some time for the drops to be absorbed.

Interaction with other drugs

Tests studying the interaction of substances with drugs, were not conducted.   In theory, it enhances the action of drugs that depress the central nervous system. These include sedatives, anesthetics, alcohol, barbiturates and opioids.

Interaction with other types of substances is unlikely due to the fact that   Bimatoprost enters the blood in low concentrations. The tests also revealed no interaction with β-blockers.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation, as it enters the body and actively affects it. In addition, Bimatoprost enters the mammary glands. For these reasons, the drug should not be used in these cases.

Bimatoprost Overdose

  • Do not exceed the recommended dose. Excessive use of the drug does not relieve your condition, and can also cause poisoning and serious side effects. If you know about an overdose case   Bimatoprost, contact the rescue service, the nearest hospital or hospital. Be sure to take with you the packaging, container or name of the drug to facilitate the diagnosis.
  • Do not pass your preparations to other people, even if they are in the same state as you, or it seems to you that your states have a number of similar symptoms, since This can lead to an overdose.
  • Please consult your healthcare professional or pharmacist, and also review the information on the product packaging.

Bimatoprost storage

  • Store the preparations at room temperature, in a cool place and away from direct sunlight. Do not expose these preparations to freezing if such a requirement is directly absent from the instructions. Keep medicines away from animals and children.
  • Do not flush the drugs in the toilet or drainage system, if such a requirement is not directly in the instructions. Medicines disposed of in this way can cause significant harm to the environment. For more information on recycling Bimatoprost contact your health care provider.

Expired Bimatoprost

  • Even one trick   Bimatoprost Expiry date may have serious consequences. Be sure to consult your healthcare professional if you feel weak or sore. In addition, the drug expired may lose its effectiveness in the fight against your disease. To ensure your own safety, it is extremely important to refuse to take expired medications. If you suffer from a disease that requires constant medication (heart disease, convulsions, life-threatening allergies), you need to establish a reliable channel of communication with your drug supplier in order to constantly have available fresh medicines with a normal shelf life.

Side effects

When using the drug for its intended purpose – against glaucoma and increased intraocular pressure, the following side effects may occur:

  • headache and dizziness;
  • irritation, severe itching, burning, redness;
  • lacrimation;
  • dryness;
  • swelling;
  • eye fatigue;
  • superficial keratitis
  • corneal destruction;
  • allergic conjunctivitis;
  • blepharitis;
  • reduced clarity of vision;
  • pain sensations;
  • photophobia;
  • temporary change in the color of the iris;
  • hemorrhagic changes;
  • uveitis;
  • hypertension.


The substance has a number of contraindications that prohibit their use:

  • pregnancy;
  • lactation period;
  • age up to 18 years;
  • allergic to components of the drug.

Drops are used with caution when:

  • aphakia, pseudophakia;
  • risk of macula edema;
  • diabetes;
  • nephropathy;
  • high cholesterol;
  • low blood pressure;
  • damage to the posterior lens capsule;
  • believe it.


Cases of overdose with local use of the drug is not fixed.


There are common drug analogues on the market that have a similar effect:

  • Bimat;
  • Lumigan;
  • Xlash;
  • Azopt;
  • Betoptik;
  • Xalac;
  • Fotil.


“A good result, eyelashes really grew up (not so, of course, as in numerous reviews, but still not bad), and, moreover, the color of eyelashes became darker. It is a pity that this effect quickly disappears when you stop using the drug”.


“I want to have good, fluffy eyelashes for everyone, including me. A lot of positive reviews about Bimatoprost are posted on the network. I found the drug a bit expensive, but I did not find cheaper analogues. However, after two weeks I saw the effect I really liked it. However, the side effects forced me to see a doctor who explained the mechanism of action of Bimatoprost and its analogues on the eyes and advised me to stop using it until persistent violations had formed. Beautiful cilia are, of course, good Oh, but intraocular pressure is better not to joke.”


“I used Bimatoprost for about two months to improve the state of eyelashes. I was tempted by reviews and beautiful pictures from advertising sites depicting lush, luxurious eyelashes. The result was not so luxurious. Of course, in the first two or three weeks the growth of eyelashes increased. However, then suddenly it stopped. despite the daily use of drops. My eyes began to itch and reddened. The doctor advised me to temporarily stop using Bimatoprost. The symptoms diminished, but I did not return to treatment anymore, it was too uncomfortable to be treated.”

How to cope with depression during pregnancy?

Posted on July 10, 2019  in Uncategorized

Pregnancy is accompanied by significant changes in the work of the whole body of a woman. The development of female sex hormones before gestation occurred cyclically: from one menstrual cycle to another. After the fertilization of the egg by the sperm and attachment of the embryo to the wall of the uterus, fluctuations in the hormonal background are aimed at maintaining pregnancy, ensuring the growth and development of the fetus. The mood swings that occurred before the onset of menstruation due to the production of the hormone progesterone and the drop in the level of estrogen, in some women increase during pregnancy. MedAboutMe introduces future parents with the causes of bad mood and depression in pregnant women, and also talks about methods for correcting the condition.

Perception of pregnancy

Getting a long-awaited positive result on beta hCG is a real celebration for the whole family. Unfortunately, not always the onset of pregnancy is a joyful moment. In the event that the parents decide to leave the child, you need to be aware of what can contribute to the development of a depressive state during pregnancy.

What is depression in pregnant women?

Depression is a condition that is accompanied by a depressed, bad mood, tearfulness, with which it is difficult for a woman to cope on her own without the availability of relevant knowledge and experience.

Risk factors for depression

  • Heredity

Scientists have identified the relationship between the emergence of depression between generations. The probability of its development increases in the event that a mother or grandmother is emotionally difficult to experience her   pregnancy.

  • Tension in communicating with the father of the child

The lack of harmony in the family is one of the main risk factors for the development of prenatal depression. Mood swings that occur in a woman in a “position” can not be tolerated by every man. The deterioration of relationships is promoted by a change in the external parameters of the body, a gain of excess weight during gestation, as well as a lack of sex life.

  • Stressful situations

Emotional overstrain, stressful situations occur in the life of every person everywhere. An unpleasant conversation with the authorities, a missed alarm clock, quarrels and conflict situations can unbalance anyone. Intrauterine development of the fetus helps to enhance the perception of events occurring in the surrounding world. This is explained both by a change in the hormonal background, and the development of a protective reaction of the body – the maternal instinct, since the woman is now responsible not only for herself, but also for her future offspring.

  • Accompanying illnesses

Infections, inflammatory processes during pregnancy, exacerbation of chronic diseases, febrile and pain syndrome weaken the immune system, at the same time contribute to the development   depressed.

  • Risk of miscarriage

The uncertainty that arises when the pregnancy is threatened is able to knock even the most emotionally resistant people out of the rut.

How can parents cope with emotional experiences?

The accumulated knowledge of the medical community has allowed to develop a comprehensive strategy for the correction of mood swings during pregnancy. Following the recommendations of obstetrician-gynecologists and medical psychologists allows minimizing the risks of depression in women in the “position”, as well as create a favorable environment for preparing for childbirth.

  • Changing attitudes to stressful situations

Parents who have revised their attitude to everyday stress, which occurs at work and in interpersonal relationships, have reduced the likelihood of a bad mood and tearfulness. Respiratory and meditative practices help to strengthen the spirit, inner spirit.

  • Creating a favorable family environment

The family is a fortress for every member of the family. The establishment of relations between the father of the child and the future mother is promoted by a joint pleasant pastime. Going to the theater, trips to nature, watching movies (which everyone was going to watch, but did not find the time) – everyone chooses something for themselves. It should be remembered that scientists have proven: sexual relationships are an opportunity to harmonize relationships in a family, because during orgasm there is a release of joy hormones (endorphins). Before resuming sexual activity, it is necessary to consult a physician to identify the absence of contraindications to sexual intercourse.

  • Recuperation

As you know, during pregnancy a woman’s body may fall into the so-called hibernation. All efforts are aimed at ensuring adequate growth and development of the fetus. That is why, so that a bad mood does not arise, a pregnant woman needs to rest and get enough sleep every day, find time for herself. Having filled life with small and big joys, you can forget about the existence of a bad mood.

  • Exercise stress

Dosed walks in the fresh air in the company of close friends contribute to the maintenance of muscle tone, as well as the fight against the blues.

  • Proper nutrition

Balanced nutrition during   of pregnancy   allows you to keep the body in shape, reduces the risk of gestational edema. In the morning, you can allow yourself a little more in the diet and eat bitter chocolate up to thirty-five grams per day.

  • Herbal infusions

In order to relax and achieve a mild sedative effect, obstetrician-gynecologists in some cases prescribe valerian extract one or two tablets several times a day. It should be remembered that   valerian   absolutely safe and does not adversely affect the fetus.

Depression is a clinical condition that can be corrected with the availability of knowledge and skills, as well as with the right approach. In the most severe cases, medical psychologists come to the aid of parents.

Depression during pregnancy: causes and methods of struggle

Posted on July 6, 2019  in Uncategorized

Most women during pregnancy enjoy their position and are in a good mood, anticipating the birth of a baby. However, the load experienced by the expectant mother and hormonal failure often negatively affect not only the physical, but also the emotional state. Any trifle can upset a woman’s mental equilibrium, provoke depression — a mental disorder accompanied by anxiety, depression, depression, lack of interest in life, and a bad mood.

This condition can occur absolutely at any stage of pregnancy. It negatively affects not only the woman, but also the formation, development, health of the child. Therefore, it is very important to know the symptoms of prenatal depression in order to recognize and eliminate it in time, as well as preventive measures to prevent the occurrence of this problem.

Causes of depression during pregnancy

Many factors can trigger the onset of prenatal depression. The main ones are:

  • mental illness before pregnancy and withdrawal of medication;
  • unwanted pregnancy;
  • predisposition to nervous disorders;
  • depressed state in the next of kin;
  • material and psychological problems in the family;
  • unsuccessful previous pregnancy or severe current;
  • fear of the upcoming changes associated with the birth of a baby;
  • forced change of scenery (for example, relocation);
  • lack of attention from loved ones, communication with friends;
  • changes in appearance;
  • fears of the future mother for the health and life of the child;
  • fear of childbirth;
  • professional lack of implementation, the inability to continue to build a career;
  • death of relatives, etc.

Symptoms of the problem

Prenatal   depression   it manifests itself in different ways, but some of its symptoms may indicate the presence of health problems (for example, a malfunction of the thyroid gland). Therefore, for a reliable diagnosis of the disorder, you need to seek help from a psychotherapist. The most disturbing symptoms of prenatal depression:

  • depressed mood or abrupt change of it;
  • detachment from all that is happening;
  • impaired concentration of attention, sleep and appetite;
  • pathological fatigue;
  • panic attacks;
  • frequent headaches;
  • delayed reaction;
  • increased nervous irritability;
  • tearfulness, which is peculiar to many during pregnancy;
  • feeling of own uselessness, lack of realization in life;
  • isolation;
  • suicidal thoughts.

Distinctive features of depression at different stages of pregnancy

Pregnancy of a woman proceeds in 3 stages (1st, 2nd and 3rd trimesters), and depression can appear on each of them. Naturally, signs of the development of the disease in each of these periods will be different.

  • First trimester

At this stage, the expectant mother may fall into depression due to the non-perception of her new state, moral unpreparedness for the early birth of the child, rethinking of what is happening. In the first trimester, pregnant women can be extremely irritable, emotional, or depressed, which can also be triggered by changes in hormonal levels. Guards should talk about the meaninglessness of life.

  • Second trimester

At this time, depression occurs most often. It provokes uncertainty in their own desires. Women are worried about what they will do before delivery, as well as after the birth of the baby, and everyone copes with these emotions differently. Some discover new talents and develop in this path. Others can not cope with the experiences, close, can not accept this state of affairs and fall into depression.

  • Third trimester

At this stage   of pregnancy   The woman’s psyche is undergoing the greatest changes. The future mother is upset about the changed shape, feels helpless, clumsy, ugly and unwanted, worries about the upcoming birth, feels her uselessness and uselessness after leaving the decree. All this affects her psycho-emotional state and contributes to the development of depression.

Difference from a bad mood

The duration and causes of appearance are the main differences between depression and bad mood. Mental disorder is more protracted and deep, it occurs as a result of the presence of one or more of the above factors, and it is difficult to confuse it with a bad mood.

Poor mood is short-lived, occurs due to the presence of negative, annoying factors and passes as a result of the influence of positive ones.

What is dangerous depression in the expectant mother

The fetus in the womb of a pregnant woman forms and develops throughout the entire 9 months, so the unstable psychoemotional state of the mother can harm the baby at any time during pregnancy. Prenatal depression is dangerous in that it can:

  • provoke a miscarriage, worsen the course of pregnancy;
  • negatively affect the development of the fetus, its weight and psyche;
  • prevent the formation of language skills in the child, etc.

Treatment and Prevention of Depression

If you identify one of the signs of a depressive disorder, a pregnant woman should be taken to a psychotherapist who will help cure the ailment and tell you how it is performed.   prevention. Ways to deal with the problem:

  • changing the mode of the day, the inclusion in it of affairs and events that elevate the mood, the per-minute distribution of daily work;
  • playing sports (if there are no contraindications);
  • proper rest and sleep;
  • communicating with positive people, visiting circles;
  • changing nutrition, including healthy foods and natural anti-depressants (chocolate, bananas, green tea, almonds, etc.) in the diet;
  • help from relatives, social support (participation in the program of psychological assistance to pregnant women);
  • self-help – the adoption of a new state, positive thinking, daily hobbies;
  • communication with nature – walks in the fresh air, especially in sunny weather;
  • taking vitamins, herbal antidepressants (lemongrass tincture, passionflower or St. John’s wort – with the permission of the doctor);
  • treatment with medicines (only in difficult cases and on the recommendation of a specialist).

In addition, excellent prevention of prenatal depression is self-care. A hike in a beauty salon, a massage room, a relaxing bath, as well as shopping always lifted women’s spirits and relieved stress.

Why can’t I ignore depression?

Posted on July 2, 2019  in Uncategorized

Currently, depression is a disease that affects more than 50% of the population. Its manifestations may be obvious or hidden, which significantly impairs the diagnostic and clinical picture of human health. Both women and men are prone to depression. Divorces in families where one of the partners is prone to its manifestations, occur several times more often. Ignoring dangerous symptoms not only undermines mental and physical health, but can also lead to suicide. What else is dangerous   depression, if you do not notice its manifestations in time and do not begin treatment?

How depression affects the psyche

Experts call depression a 21st century disease. Its development is promoted by a high rhythm of life, a low level of economic stability, the presence of unidentified psychological traumas, inability to take care of oneself, bad habits, stress, lack of support.

Sometimes people confuse depressive manifestations with bad mood, fatigue and other signs that relate to the peculiarities of character. Depression is characterized by prolonged manifestations, in contrast to what is considered behavioral features. Its main features are:

  • lack of strength and joy to life;
  • unwillingness to do things that used to be enjoyable;
  • sleep disturbance, refusal to eat or overeating;
  • irritability, tearfulness, aggressiveness;
  • quick temper, frequent mood swings, bouts of rage;
  • lack of control over feelings, thoughts and behavior;
  • obsessive desire to disappear;
  • unwillingness to wake up, live, move, work;
  • lack of necessary care about yourself – a person stops taking a bath, does not monitor the cleanliness of clothes, and order;
  • rejection of the activity;
  • feeling of unreality of the events;
  • strong anxiety attacks   before bedtime;
  • feeling of lack of meaning in life.

The human psyche is acutely responsive to depressive manifestations. The formation of processes that are responsible for making decisions, the ability to make choices, overcoming difficulties is slowing down. A person feels that he is inside, as if he is dead and does not see ways to help himself. A sense of confusion, loss of objectivity. People who are depressed, when asked what they feel, are often told that their “As if not.” This sensation causes fear to go crazy, a new wave of disturbing thoughts. They strive desperately to look for something that can give them joy, however, they do not find it and then experience a new stage of desolation. Others do not resist the negative manifestations that occur in the psyche and “go to die.” If this process is not stopped in time, the consequences can be dire.

A depressed person does not manipulate others, demonstrating that he is ill, he does not want anything and nothing pleases him – he really feels that way and does not understand why he should live. Therefore, the help and support of loved ones, the opportunity to notice in time that  depression   swallowed a family member or friend – a chance to figure out what caused it and ask for medical and psychotherapeutic help.

Communication disorders

Many people ignore depressive symptoms and, from their last strength, continue to live, go to work, communicate. How is their interaction with others built?

  • They can be unpredictable – even 5 minutes ago there was a smile on their face and they seemed to be feeling good, but now they want to cry bitterly and die.
  • Depression postpones the communication style. In the middle of a conversation, business or friendly, people can “hang on”, step back and “fall” into their thoughts. In fact, they are close to others – even keep up the conversation – however, they are mentally somewhere far away.
  • A person who is “confused” in life, suffers from the influence of psychological trauma, can often be biased towards others – he is inclined to take the words of others very close to his heart, be offended to tears, “tear” meaningful relationships, blame unfairly, leave or attack. He does this because he projects to those around him unexpressed feelings that cause depressive manifestations and should be addressed to other people – parents, relatives, partners.

Thus, depression, the treatment of which is not engaged, can lead to the fact that many valuable contacts in life are lost, there is a risk of losing friends, provoking quarrels and conflicts.

The risk of losing meaningful relationships

It is difficult to build a close relationship with a person who is depressed and does not recognize it. He cannot calmly and correctly perceive the words of others, be fair, think objectively. Instead, he takes everything into his own account – he sees “enemies”, suspects, is jealous, attacks, after which he feels unloved and suffers.

Lack of vitality

When the psyche is at the mercy of depression, it is impossible to think of anything else, as the absence of meaning in life and ways of leaving it. For this reason, the person has almost no desire to do anything – he physically feels a lack of energy and fatigue, as if he had to work for several days all the time. This feeling does not leave him, even if he sleeps, rests and does not refuse food.

Exacerbation of somatic diseases

According to experts, people who are prone to depressive manifestations, more often than others, exacerbated chronic diseases. So, they suffer from heart disease, disorders of the circulatory, respiratory systems, gastrointestinal tract. When a person, after he completely “plunges” into illnesses, still seeks help from a doctor – a cardiologist, a psychotherapist – he is much harder to recover from all painful symptoms, it takes a lot of time and effort to diagnose and correct.

Treatment of depression psychotherapy

The lack of vitality is due to the containment of negative feelings. For the same reason, people may suffer from depression. If you turn to a psychotherapist for help at the moment when disturbances in the emotional sphere or at the physical level become noticeable, you can get rid of depressive manifestations with almost one hundred percent success.

The more a person “runs away” from depression, not allowing himself to notice it, the worse may be the consequences for his life and health. Psychotherapy does not allow “hiding” from itself, even if this meeting promises something unpleasant, dangerous, painful. The support of a psychotherapist, to whom trust is formed, is a chance to build relationships with oneself, improve one’s health, fully recover from depression.

Depression in a young father

Posted on June 28, 2019  in Uncategorized

After giving birth, mother and baby are in constant contact. And what does the new father feel at this time? What feelings seethe in his soul after the birth of an heir? Unfortunately, these are not always only positive emotions.

Depression in men: signs of the disease

On depression, the young father began to talk only in recent years. It turns out that depressive states are inherent in about 10% of men who have recently become dads. Why does this happen, MedAboutMe understood.

It is sometimes more difficult for men to endure depression because they often simply do not understand what is happening to them. The new father becomes sluggish and irritable, gets tired faster and tries his best to avoid homework. And if a woman tries to shame and call him to order, he either leaves a serious conversation, or shows violent negative   emotions: “So, I do not do anything? Now I will definitely not do anything! See how you like it. “

A young father in a state of depression separates from the family, including the child, not wanting to communicate with him. However, he is not just not in contact with the newborn, fearing to harm the crumbs because of his own awkwardness, but consciously does not want to see him. It seems that the child is unloved by his own father and uninteresting to him.

The fact that a man   depression also shows an increase in the amount of time spent by him outside the home. He explains his own absence very reluctantly, in most cases referring to increased workloads at work, or refuses to do so at all. And then again he uses any excuse to sneak out of the house.

Stress and other causes of depressive disorders in a young father

The newly minted daddy can “knock out” both the new status and the unwillingness to perform fatherly duties (although this does not mean that the man didn’t want this child) and the problems that accompany this joyful event. Sharply increased material needs of the family, combined with a lack of knowledge and experience in dealing with young children, are fertile ground for the development of depressive disorders.

The next factor of development   diseases   There are certain discrepancies between expectations and reality. Very often, the future father draws in his imagination a charming calm toddler, but in reality the child is not exactly like that – he cries, requires food, constant attention and care.Therefore, it is not surprising that a man becomes depressed. Claims and demands of the spouses are also fertile ground for stress. The trigger can be fatigue and overwork, new responsibilities, greater responsibility and a lack of funds to meet the increased needs of the family.

Depression is even more aggravated if the wife is constantly busy with a small child, and practically does not pay attention to the man.

Very often, a man experiencing a complex range of feelings in connection with the advent of the heir is not able to express them. He does not complain, but, on the contrary, tries to look in the eyes of loved ones as prescribed by social stereotypes, according to which a man should not be weak and hesitant. He must be strong, confident and reliable.

The child was born: how to cope with emotions?

How to cope with postpartum depression? First of all – no self-medication and taking antidepressants on the advice of “knowledgeable” friends. Only a specialist (psychiatrist or psychotherapist) can prescribe medication. What helped one person may well turn out to be not only useless for the other, but also harmful. In addition, the drug and its dose are selected individually.

And do not blame yourself for the fact that negative emotions prevail. The appearance of symptoms of depressive disorder does not mean that this man is a bad father. Therefore, the feeling of guilt is better to drive away away. But you should not write off your own inaction and the lack of positive emotions for depression either. So a man can justify himself for a very long time, assuring that depression is to blame for everything, and do nothing to change the situation for the better.

To improve their mental state, young parents should not only engage the child, but also pay attention to themselves and to each other. The best helpers in the fight against the blues – sincerity, friendly support and understanding. In addition, the young dad will be useful to take a break to restore mental strength. For example, a man can spend a couple of evenings a month the way he wants (of course, within reason).

Well, if you can not cope with depression on your own, it makes sense to consult a specialist. Currently, there are many ways to treat depression – from a variety of psychotherapeutic techniques to conducting drug therapy.

Can help a man out of depression and people close to him. Therefore, a few tips for them. If one of the relatives has been overwhelmed with depression, this state should not be ignored, it is better to support the person. You don’t need to say something like: “You’ve been inventing everything, you don’t have any depression,” “It’s much harder for others, but they don’t even give way to it”, “Stop souring and take hold of yourself”. Such “support” not only does not help, but can aggravate the situation even more, because the person will feel ignored and misunderstood. It is unlikely that he will be better off.

No need to blame the young father in the absence of willpower, indifferent attitude to the newborn child and the loss of interest in life. This can cause even greater oppression, aggression, and even deprive the last forces. A man sometimes needs help no less than a woman. Help him, for example, take on a part of his duties (to a greater extent – domestic). Do not wait for requests, offer help yourself. And as often as possible, praise zahandrivshego person.

“Likes” in social networks do not save from depression

Posted on June 24, 2019  in Uncategorized

American sociologists from the National Institute of Mental Health argue that good events on social networks do not outweigh the negative comments. With each “dyslikom” risk   depressed   will increase despite the number of “likes” received.

The study involved almost 1.2 thousand students aged 18 to 30 years. They were asked to assess the percentage of negative and positive communication in social networks, as well as to pass tests for depression. Scientists, moreover, were interested in how often last week the project participants felt depressed, helpless, useless, and so on.

It turned out that negative comments significantly increase the risk of developing depression in people. The increase in the volume of negative comments by only 10% causes an increase in the probability of developing a depressive state by 20%.

What is the most annoying – positive feedback, positive pictures, “likes” do not improve the user’s mood and do not reduce the risk of developing mental disorder.

Experts urge people to “disconnect” from social networks as often as possible in order not to allow them to enter themselves into a state of depression. According to them, even the publication of other people’s photos of a successful happy life can lead to this, as people are used to comparing themselves with others. And often, the comparison of the demo “photo-shocked” picture is not in their favor.